Publications

Ronni A.G. da Silva, Brenda Yin Qi Tien, Patrick Hsien Neng Kao, Haris Antypas, Cenk Celik, Ai Zhu Casandra Tan, Muhammad Hafiz Ismail, Guangan Hu, Kelvin Kian Long Chong, Guillaume Thibault, Jianzhu Chen, Kimberly A. Kline ✉

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Cell Host & Microbe 2026 January 27. doi 10.1016/j.chom.2026.01.002

Aaron Ming Zhi Tan, Cenk Celik, Stella Yue Ting Lee, Mark Veleba, Caroline S. Manzano, Rahim MK Abdul, Guillaume Thibault ✉, Kimberly A. Kline ✉

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

Science Advances 2026 January 16. doi 10.1126/sciadv.aeb5297

Cell Scientists to Watch. Interview with Guillaume Thibault – President of the Society for Cell Biology Singapore

Journal of Cell Science 2025 September 18. doi 10.1242/jcs.264358

Zengxin Huang, Wei Wang, Yilin Wang, Hangfeng Li, Mengqing Xu, Anastasiia Fadieieva, Guillaume Thibault, Pakorn Kanchanawong ✉

Enhanced nanoscale molecular dynamics mapping in live cells by galvo-accelerated single-molecule displacement analysis

Optica 2025 September 4. doi 10.1364/OPTICA.564509

Qian Yee Woo, Bernett TK Lee, Lee Wei Lim, Jingtao Zhang, Ayumu Tashiro, Pheck Khee Lau, Guillaume Thibault, Yulan Wang, Valerie C.L. Lin ✉

Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood

Nutritional Neuroscience 2025 August 25. doi 10.1080/1028415X.2025.2546946

Shan Chun Lim, Manoj Itharajula, Mads Harder Møller, Rohan Shawn Sunil, Kevin Fo, Yu Song Chuah, Herman Foo, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil ✉

PlantConnectome: a knowledge graph database encompassing >71,000 plant articles

The Plant Cell 2025 July 23. doi 10.1093/plcell/koaf169

Mani R Kumar, Karthick Raja Arulprakasam, An-Nikol Kutevska, Marek Mutwil ✉, Guillaume Thibault ✉

Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe

Journal of Molecular Biology 2025 Mar 15. doi 10.1016/j.jmb.2025.169072

Karthick Raja Arulprakasam, Jenella Wing Shan Toh, Herman Foo, Mani R Kumar, An-Nikol Kutevska, Emilia Emmanuelle Davey, Marek Mutwil ✉, Guillaume Thibault ✉

Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps

BMC Genomics 2024 Nov 13. doi 10.1186/s12864-024-10997-6

Cenk Celik, Stella Yue Ting Lee, Frederick Reinhart Tanoto, Mark Veleba, Kimberly A. Kline ✉, Guillaume Thibault ✉

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

eLife 2024 May 20. doi 10.7554/eLife.95113.3

Melina Casadio ✉

A cell biological perspective on Singapore’s scientific growth (Q&A)

Nature Cell Biology 2023 Jan 23. doi 10.1038/s41556-022-01070-z

Contributors Wanjin Hong and Guillaume Thibault

Cenk Celik*, Stella Yue Ting Lee*, Wei Sheng Yap, Guillaume Thibault ✉

Endoplasmic reticulum stress and lipids in health and diseases

Progress in Lipid Research 2023 Jan. doi 10.1016/j.plipres.2022.101198

Top cited article in Progress in Lipid Research since January 2023 (Scopus)

Reut Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, Ilana Lebenthal-Loinger, Sarit Karako-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, Sivan Henis-Korenblit ✉

Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism

Cell Reports 2022 Nov 29. doi 10.1016/j.celrep.2022.111739

Wei Sheng Yap, Guillaume Thibault ✉

A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE

MicroPubl Biology 2022 Oct 26. doi 10.17912/micropub.biology.000657

Caroline Beaudoin-Chabot*, Lei Wang*, Cenk Celik, Aishah T.F. Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, Guillaume Thibault ✉

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Nature Communications 2022 Oct 19. doi 10.1038/s41467-022-33630-0

Wei Sheng Yap, Guillaume Thibault ✉

Human PERK rescues unfolded protein response-deficient yeast cells

MicroPubl Biology 2022 Jun 22. doi 10.17912/micropub.biology.000592

Sophia Huey Shan Tan ✉, Guillaume Thibault ✉, Anna Chia Yin Chew, Preman Rajalingam

Enabling open-ended questions in team-based learning using automated marking: Impact on student achievement, learning and engagement

Journal Computer Assisted Learning 2022 May 2. doi 10.1111/jcal.12680

Nurulain Ho*, Wei Sheng Yap*, Guillaume Thibault ✉

A high-throughput genetic screening protocol to measure lipid bilayer stress-induced unfolded protein response in Saccharomyces cerevisiae

STAR Protocol 2021 Dec 17. doi 10.1016/j.xpro.2021.100868

Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Julio Diaz Caballero, Mohan Babu, Francis T.F. Tsai, Tomohide Saio, Walid A. Houry

Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

Nature Communications 2021 Jan 12. doi 10.1038/s41467-020-20553-x

Guillaume Thibault, Davis T. Ng, Vikash Verma

Concepts. Heat/Stress Responses

Encyclopedia of Biological Chemistry III Academic Press, Waltham, 2021, 97-101. doi 10.1016/B978-0-12-819460-7.00189-4

Wei Sheng Yap*, Peter Shyu Jr.*, Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault ✉

The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

Journal of Cell Science 2020 Nov 5. doi 10.1242/jcs.248526

Nurulain Ho*, Wei Sheng Yap*, Jiaming Xu*, Haoxi Wu*, Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault ✉

Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Journal of Cell Biology 2020 Apr 29. doi 10.1083/jcb.201909165

Rachel S. Kraut, Guillaume Thibault, Sarita Hebbar, Elisabeth Knust

Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance

Frontiers Media SA 2020, eBook. doi 10.3389/978-2-88963-429-3

Xiu Hui Fun, Guillaume Thibault ✉

Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes

Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan. doi 10.1016/j.bbalip.2019.04.009

Sarita Hebbar, Elisabeth Knust, Guillaume Thibault ✉, Rachel Kraut ✉

Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance

Frontiers in Cell and Developmental Biology 2019 Dec 6. doi 10.3389/fcell.2019.00327

Wilson W.B. Goh ✉, Subhash Thalappilly, Guillaume Thibault ✉

Moving beyond the current limits of data analysis in longevity and healthy lifespan studies

Drug Discovery Today 2019 Dec. doi 10.1016/j.drudis.2019.08.008

Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

Cell Reports 2019 Jul 23. doi 10.1016/j.celrep.2019.06.036

Peter Shyu Jr*, Benjamin S.H. Ng*, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault ✉

Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

Scientific Reports 2019 Jun 14. doi 10.1038/s41598-019-45020-6

Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault ✉

Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans

Frontiers in Physiology 2019 May 28. doi 10.3389/fphys.2019.00641

Jhee Hong Koh*, Lei Wang*, Caroline Beaudoin-Chabot, Guillaume Thibault ✉

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

Journal of Cell Science 2018 Nov 21. doi 10.1242/jcs.217992

Peter Shyu Jr*, Xing Fah Wong*, Karen Crasta ✉, Guillaume Thibault ✉

Dropping in on lipid droplets: insights into cellular stress and cancer

Bioscience Reports 2018 Sep 19, 38(5). doi 10.1042/BSR20180764

Nurulain Ho, Chengchao Xu, Guillaume Thibault ✉

From the unfolded protein response to metabolic diseases - lipids under the spotlight

Journal of Cell Science 2018 Feb 8;131(3). doi 10.1242/jcs.199307

Haoxi Wu*, Benjamin S.H. Ng*, Guillaume Thibault ✉

Endoplasmic Reticulum Stress Response in Yeast and Humans

Bioscience Reports 2014 Aug 1, 34(4). doi 10.1042/BSR20140058

Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng

Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway

Science 2013, 340, 978-981. doi 10.1126/science.1234055

Research Highlights in Nature Chemical Biology

Guillaume Thibault ✉, Davis T. Ng

Heat/Stress Responses

Encyclopedia of Biological Chemistry Academic Press, Waltham, 2013, 522-525. doi 10.1016/B978-0-12-378630-2.00427-8

Guillaume Thibault, Davis T. Ng

The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast

Cold Spring Harbor Perspectives in Biology 2012 Dec 3;4(12):a013193. doi 10.1101/cshperspect.a013193

Guillaume Thibault, Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng

The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network

Molecular Cell 2012, 48, 16-27. doi 10.1016/j.molcel.2012.08.016

Guillaume Thibault, Walid A. Houry

The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O

Journal of Physical Chemistry B 2012, 116, 6717-6724. doi 10.1021/jp212024b

Guillaume Thibault*, Nurzian Ismail*, Davis T. Ng

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

PNAS 2011, 108, 20597-20602. doi 10.1073/pnas.1117184109

Songyu Wang, Guillaume Thibault, Davis T. Ng

Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity

Journal of Biological Chemistry 2011, 286, 29376-23987. doi 10.1074/jbc.M111.233346

Usheer Kanjee, Irina Gutsche, Eftichia Alexopoulos, Boyu Zhao, Majida El Bakkouri, Guillaume Thibault, Kaiyin Liu, Shaliny Ramachandran, Jamie Snider, Emil F. Pai. Walid A. Houry

Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase

EMBO Journal 2011, 30, 931-944. doi 10.1038/emboj.2011.5

Jamie Snider*, Guillaume Thibault*, Walid A. Houry

The AAA+ superfamily of functionally diverse proteins

Genome Biology 2008, 9, 216. doi 10.1186/gb-2008-9-4-216

Guillaume Thibault, Jovana Yudin, Philip Wong, Vladimir Tsitrin, Remco Sprangers, Rongmin Zhao, Walid A. Houry

Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX

PNAS 2006, 103, 17724-17729. doi 10.1073/pnas.0601505103

Guillaume Thibault*, Yulia Tsitrin*, Toni Davidson, Anna Gribun, Walid A. Houry

Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation

EMBO Journal 2006, 25, 3367-3376. doi 10.1038/sj.emboj.7601223

Urszula A. Wojtyra*, Guillaume Thibault*, Ashleigh Tuite, Walid A. Houry

The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function

Journal of Biological Chemistry 2003, 278, 48981-48990. doi 10.1074/jbc.M307825200