Lipid regulation and cell stress

At the Thibault Lab, based at Nanyang Technological University (NTU) and affiliated with the Mechanobiology Institute (MBI), we focus on the endoplasmic reticulum (ER), a central organelle in protein folding and lipid regulation. When disrupted, ER stress contributes to numerous conditions, from metabolic disorders and neurodegeneration to infection and tissue damage.

We explore how the ER senses different forms of stress, especially lipid bilayer stress, and how the unfolded protein response (UPR) determines whether cells adapt or undergo programmed death.