PUBLICATIONS
CLICK HERE for all publications. *co-first authors | Thibault lab members | ✉ corresponding author
orcid.org/0000-0002-7926-48122025
Shan Chun Lim, Manoj Itharajula, Mads Harder Møller, Rohan Shawn Sunil, Kevin Fo, Yu Song Chuah, Herman Foo, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil✉
PlantConnectome: a knowledge graph database encompassing >71,000 plant articles
The Plant Cell 2025 July 23. doi. 10.1093/plcell/koaf169
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Article featured In Brief
Qian Yee Woo, Bernett TK Lee, Lee Wei Lim, Jingtao Zhang, Ayumu Tashiro, Pheck Khee Lau, Guillaume Thibault, Yulan Wang, Valerie C.L. Lin✉
Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age bioRxiv 2025 May 27. doi. 10.1101/2025.05.22.655437
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Mani R Kumar, Karthick Raja Arulprakasam, An-Nikol Kutevska, Marek Mutwil✉, Guillaume Thibault✉
Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe
J Mol Biol 2025 Mar 15. doi. 10.1016/j.jmb.2025.169072
Ronni A. G. da Silva, Brenda Yin Qi Tien, Patrick Hsien Neng Kao, Cenk Celik, Ai Zhu Casandra Tan, Muhammad Hafiz Ismail, Guangan Hu, Kelvin Kian Long Chong, Guillaume Thibault, Jianzhu Chen, Kimberly A. Kline✉
Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation. bioRxiv 2025 Jan 31. doi. 10.1101/2025.01.31.635924
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2024
Karthick Raja Arulprakasam, Jenella Wing Shan Toh, Herman Foo, Mani R Kumar, An-Nikol Kutevska, Emilia Emmanuelle Davey, Marek Mutwil✉, Guillaume Thibault✉
Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps
BMC Genom 2024 Nov 13. doi. 10.1186/s12864-024-10997-6
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Cenk Celik, Stella Yue Ting Lee, Frederick Reinhart Tanoto, Mark Veleba, Kimberly A. Kline✉, Guillaume Thibault✉
Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
eLife 2024 May 20. doi. 10.7554/eLife.95113.3
Abstract | Full Text | PDF | Raw data | Processed data
Article featured in eLife Digest
2023
Kevin Fo, Yu Song Chuah, Herman Fyh, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil✉
PlantConnectome: knowledge networks encompassing >100,000 plant article abstracts
bioRxiv 2023 Jul 11. doi. 10.1101/2023.07.11.548541
Abstract | PDF
Melina Casadio✉
Contributors - Wanjin Hong and Guillaume Thibault
A cell biological perspective on Singapore’s scientific growth (Q&A)
Nat Cell Biol 2023 Jan 23. doi.10.1038/s41556-022-01070-z
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Cenk Celik*, Stella Yue Ting Lee*, Wei Sheng Yap, Guillaume Thibault✉
Endoplasmic reticulum stress and lipids in health and diseases
Prog Lipid Res 2023 Jan. doi.10.1016/j.plipres.2022.101198
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2022
R. Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, I. Lebenthal-Loinger, S. Karato-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, S. Henis-Korenblit✉
Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
Cell Reports 2022 Nov 29. doi.10.1016/j.celrep.2022.111739
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Wei Sheng Yap and Guillaume Thibault✉
A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE
MicroPubl Biol 2022 Oct 26. doi.10.17912/micropub.biology.000657
Abstract | Full Text | PDF | Data Repository
Caroline Beaudoin-Chabot*, Lei Wang*, Cenk Celik, Aishah T.F. Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, and Guillaume Thibault✉
The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans
Nat Commun 2022 Oct 19. doi. 10.1038/s41467-022-33630-0
Abstract | Full Text | PDF | Data Repository
NTU NEWS | NTU Press Release
Local Media Coverage CNA938 Singapore Today, Straits Times, zaobao
International Media Coverage Big News Network, Borneo Bulletin, Canaltech, Forbes Russia, Psychreg, Revyuh, terra, and Yahoo! News
Wei Sheng Yap and Guillaume Thibault✉
Human PERK rescues unfolded protein response-deficient yeast cells
MicroPubl Biol 2022 Jun 22. doi. 10.17912/micropub.biology.000592
Abstract | Full Text | PDF | Data Repository
Sophia Huey Shan Tan✉, Guillaume Thibault✉, Anna Chia Yin Chew, Preman Rajalingam
Enabling open-ended questions in team-based learning using automated marking: Impact on student achievement, learning and engagement
J Comput Assist Learn 2022 May 2. doi. 10.1111/jcal.12680
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2021
Nurulain Ho*, Wei Sheng Yap*, Guillaume Thibault✉
A high-throughput genetic screening protocol to measure lipid bilayer stress-induced unfolded protein response in Saccharomyces cerevisiae
STAR Protoc 2021 Dec 17. doi. 10.1016/j.xpro.2021.100868
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K. Rizzolo, A.Y.H. Yu, A. Ologbenla, S.R. Kim, H. Zhu, K. Ishimori, Guillaume Thibault, E. Leung, Y.W. Zhang, M. Teng, M. Haniszewski, N. Miah, S. Phanse, Z. Minic, S. Lee, J.D. Caballero, M. Babu, F.T.F. Tsai, T. Saio, W.A. Houry
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
Nat Commun 2021 Jan 12. doi. 10.1038/s41467-020-20553-x
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Guillaume Thibault, Davis T. Ng, Vikash Verma
Concepts | Heat/Stress Responses
Encyclopedia of Biological Chemistry III, Academic Press, Waltham, 2021, 97-101. doi. 10.1016/B978-0-12-819460-7.00189-4
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2020
Wei Sheng Yap*, Peter Shyu Jr.*, Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉
The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis
J Cell Sci 2020 Nov 5. doi. 10.1242/jcs.248526
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Article featured in Research Highlight
Wei Sheng Yap featured as First Person in the same issue
Preprint of this publication was highlighted in preLights
Nurulain Ho*, Wei Sheng Yap*, Jiaming Xu*, Haoxi Wu*, Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
J Cell Biol 2020 Apr 29. doi. 10.1083/jcb.201909165
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Rachel S. Kraut, Guillaume Thibault, Sarita Hebbar, Elisabeth Knust, eds.
Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Frontiers Media SA. doi. 10.3389/978-2-88963-429-3
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Xiu Hui Fun and Guillaume Thibault✉
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan doi. 10.1016/j.bbalip.2019.04.009
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2019
Sarita Hebbar, Elisabeth Knust, Guillaume Thibault✉, Rachel Kraut✉
Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Front Cell Dev Biol 2019 Dec 6. doi. 10.3389/fcell.2019.00327
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Wilson W.B. Goh✉, Subhash Thalappilly, Guillaume Thibault✉
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Drug Discov Today 2019 Dec. doi. 10.1016/j.drudis.2019.08.008
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Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Cell Rep 2019 Jul 23. doi. 10.1016/j.celrep.2019.06.036
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Peter Shyu Jr*, Benjamin S.H. Ng*, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault✉
Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
Sci Rep 2019 Jun 14. doi. 10.1038/s41598-019-45020-6
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Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault✉
Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans
Front Physiol 2019 May 28. doi. 10.3389/fphys.2019.00641
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2018
Jhee Hong Koh*, Lei Wang*, Caroline Beaudoin-Chabot, Guillaume Thibault✉
Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
J Cell Sci 2018 Nov 21. doi. 10.1242/jcs.217992
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Peter Shyu Jr*, Xing Fah Wong*, Karen Crasta✉, Guillaume Thibault✉
Dropping in on lipid droplets: insights into cellular stress and cancer
Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
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Nurulain Ho, Chengchao Xu, Guillaume Thibault✉
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
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2014
Haoxi Wu*, Benjamin S.H. Ng*, Guillaume Thibault✉
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep 2014 Aug 1, 34(4). doi. 10.1042/BSR20140058
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2013
Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981. doi. 10.1126/science.1234055
Abstract I Full Text I Perspective in Science I Research Highlights in Nature Chemical Biology I Faculty Opinions
Guillaume Thibault✉ and Davis T. Ng
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525. doi. 10.1016/B978-0-12-378630-2.00427-8
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2012
Guillaume Thibault and Davis T. Ng
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193. doi. 10.1101/cshperspect.a013193
Abstract I Full Text
Guillaume Thibault , Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27. doi. 10.1016/j.molcel.2012.08.016
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Guillaume Thibault and Walid A. Houry
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724. doi. 10.1021/jp212024b
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2011
Guillaume Thibault*, Nurzian Ismail*, Davis T. Ng
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602. doi. 10.1073/pnas.1117184109
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Songyu Wang, Guillaume Thibault, Davis T. Ng
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987. doi. 10.1074/jbc.M111.233346
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Usheer Kanjee, Irina Gutsche, Eftichia Alexopoulos, Boyu Zhao, Majida El Bakkouri, Guillaume Thibault, Kaiyin Liu, Shaliny Ramachandran, Jamie Snider, Emil F. Pai. Walid A. Houry
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944. doi. 10.1038/emboj.2011.5
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2008
Jamie Snider*, Guillaume Thibault*, Walid A. Houry
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216. doi. 10.1186/gb-2008-9-4-216
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2006
Guillaume Thibault, Jovana Yudin, Philip Wong, Vladimir Tsitrin, Remco Sprangers, Rongmin Zhao, Walid A. Houry
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729. doi. 10.1073/pnas.0601505103
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Guillaume Thibault*, Yulia Tsitrin*, Toni Davidson, Anna Gribun, Walid A. Houry
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376. doi. 10.1038/sj.emboj.7601223
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2003
Urszula A. Wojtyra*, Guillaume Thibault*, Ashleigh Tuite, Walid A. Houry
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990. doi. 10.1074/jbc.M307825200
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