PUBLICATIONS
CLICK HERE for all publications. *co-first authors | Thibault lab members | ✉ corresponding author
orcid.org/0000-0002-7926-48122026
Ronni A.G. da Silva, Brenda Yin Qi Tien, Patrick Hsien Neng Kao, Haris Antypas, Cenk Celik, Ai Zhu Casandra Tan, Muhammad Hafiz Ismail, Guangan Hu, Kelvin Kian Long Chong, Guillaume Thibault, Jianzhu Chen, Kimberly A. Kline✉
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections
Cell Host & Microbe 2026 January 27. doi. 10.1016/j.chom.2026.01.002
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Aaron Ming Zhi Tan, Cenk Celik, Stella Yue Ting Lee, Mark Veleba, Caroline S. Manzano, Rahim MK Abdul, Guillaume Thibault✉, Kimberly A. Kline✉
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
Science Advances 2026 January 16. doi. 10.1126/sciadv.aeb5297
Abstract | Full Text | PDF | Raw Data
NTU News | University of Geneve Press Release | SCELSE News
Local Media Coverage Straits Times, Tamil Murasu, zaobao
International Media Coverage including Bio Quick News, GEN, Malay Mail, Mirage News, myScience, Portal R7, SciTechDaily, the microbiologist, Vietnam Plus, Yahoo! News
2025
Cell Scientists to Watch
Interview with Guillaume Thibault – President of the Society for Cell Biology Singapore
Journal of Cell Science 2025 September 18. doi. 10.1242/jcs.264358
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Zengxin Huang, Wei Wang, Yilin Wang, Hangfeng Li, Mengqing Xu, Anastasiia Fadieieva, Guillame Thibault, and Pakorn Kanchanawong✉
Enhanced nanoscale molecular dynamics mapping in live cells by galvo-accelerated single-molecule displacement analysis
Optica 2025 September 4. doi. 10.1364/OPTICA.564509
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Qian Yee Woo, Bernett TK Lee, Lee Wei Lim, Jingtao Zhang, Ayumu Tashiro, Pheck Khee Lau, Guillaume Thibault, Yulan Wang, Valerie C.L. Lin✉
Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood
Nutritional Neuroscience 2025 August 25. doi. 10.1080/1028415X.2025.2546946
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Shan Chun Lim, Manoj Itharajula, Mads Harder Møller, Rohan Shawn Sunil, Kevin Fo, Yu Song Chuah, Herman Foo, Emilia Emmanuelle Davey, Melissa Fullwood, Guillaume Thibault, Marek Mutwil✉
PlantConnectome: a knowledge graph database encompassing >71,000 plant articles
The Plant Cell 2025 July 23. doi. 10.1093/plcell/koaf169
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Article featured In Brief
Mani R Kumar, Karthick Raja Arulprakasam, An-Nikol Kutevska, Marek Mutwil✉, Guillaume Thibault✉
Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe
Journal of Molecular Biology 2025 Mar 15. doi. 10.1016/j.jmb.2025.169072
Ronni A. G. da Silva, Brenda Yin Qi Tien, Patrick Hsien Neng Kao, Cenk Celik, Ai Zhu Casandra Tan, Muhammad Hafiz Ismail, Guangan Hu, Kelvin Kian Long Chong, Guillaume Thibault, Jianzhu Chen, Kimberly A. Kline✉
Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation. bioRxiv 2025 Jan 31. doi. 10.1101/2025.01.31.635924
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2024
Karthick Raja Arulprakasam, Jenella Wing Shan Toh, Herman Foo, Mani R Kumar, An-Nikol Kutevska, Emilia Emmanuelle Davey, Marek Mutwil✉, Guillaume Thibault✉
Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps
BMC Genomics 2024 Nov 13. doi. 10.1186/s12864-024-10997-6
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Cenk Celik, Stella Yue Ting Lee, Frederick Reinhart Tanoto, Mark Veleba, Kimberly A. Kline✉, Guillaume Thibault✉
Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
eLife 2024 May 20. doi. 10.7554/eLife.95113.3
Abstract | Full Text | PDF | Raw data | Processed data
Article featured in eLife Digest
2023
Melina Casadio✉
Contributors - Wanjin Hong and Guillaume Thibault
A cell biological perspective on Singapore’s scientific growth (Q&A)
Nature Cell Biology 2023 Jan 23. doi.10.1038/s41556-022-01070-z
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Cenk Celik*, Stella Yue Ting Lee*, Wei Sheng Yap, Guillaume Thibault✉
Endoplasmic reticulum stress and lipids in health and diseases
Progress in Lipid Research 2023 Jan. doi.10.1016/j.plipres.2022.101198
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2022
R. Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, I. Lebenthal-Loinger, S. Karato-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, S. Henis-Korenblit✉
Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
Cell Reports 2022 Nov 29. doi.10.1016/j.celrep.2022.111739
Abstract | Full Text | PDF
Wei Sheng Yap and Guillaume Thibault✉
A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE
MicroPubl Biology 2022 Oct 26. doi.10.17912/micropub.biology.000657
Abstract | Full Text | PDF | Data Repository
Caroline Beaudoin-Chabot*, Lei Wang*, Cenk Celik, Aishah T.F. Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, and Guillaume Thibault✉
The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans
Nature Communnications 2022 Oct 19. doi. 10.1038/s41467-022-33630-0
Abstract | Full Text | PDF | Data Repository
NTU NEWS | NTU Press Release
Local Media Coverage CNA938 Singapore Today, Straits Times, zaobao
International Media Coverage including Big News Network, Borneo Bulletin, Canaltech, Forbes Russia, Psychreg, Revyuh, terra, and Yahoo! News
Wei Sheng Yap and Guillaume Thibault✉
Human PERK rescues unfolded protein response-deficient yeast cells
MicroPubl Biology 2022 Jun 22. doi. 10.17912/micropub.biology.000592
Abstract | Full Text | PDF | Data Repository
Sophia Huey Shan Tan✉, Guillaume Thibault✉, Anna Chia Yin Chew, Preman Rajalingam
Enabling open-ended questions in team-based learning using automated marking: Impact on student achievement, learning and engagement
Journal Computer Assisted Learning 2022 May 2. doi. 10.1111/jcal.12680
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2021
Nurulain Ho*, Wei Sheng Yap*, Guillaume Thibault✉
A high-throughput genetic screening protocol to measure lipid bilayer stress-induced unfolded protein response in Saccharomyces cerevisiae
STAR Protocol 2021 Dec 17. doi. 10.1016/j.xpro.2021.100868
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K. Rizzolo, A.Y.H. Yu, A. Ologbenla, S.R. Kim, H. Zhu, K. Ishimori, Guillaume Thibault, E. Leung, Y.W. Zhang, M. Teng, M. Haniszewski, N. Miah, S. Phanse, Z. Minic, S. Lee, J.D. Caballero, M. Babu, F.T.F. Tsai, T. Saio, W.A. Houry
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
Nature Communications 2021 Jan 12. doi. 10.1038/s41467-020-20553-x
Abstract I Full Text I PDF
Guillaume Thibault, Davis T. Ng, Vikash Verma
Concepts | Heat/Stress Responses
Encyclopedia of Biological Chemistry III, Academic Press, Waltham, 2021, 97-101. doi. 10.1016/B978-0-12-819460-7.00189-4
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2020
Wei Sheng Yap*, Peter Shyu Jr.*, Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉
The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis
Journal of Cell Science 2020 Nov 5. doi. 10.1242/jcs.248526
Abstract I Full Text I PDF I Data Repository
Article featured in Research Highlight
Wei Sheng Yap featured as First Person in the same issue
Preprint of this publication was highlighted in preLights
Nurulain Ho*, Wei Sheng Yap*, Jiaming Xu*, Haoxi Wu*, Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Journal of Cell Biology 2020 Apr 29. doi. 10.1083/jcb.201909165
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Rachel S. Kraut, Guillaume Thibault, Sarita Hebbar, Elisabeth Knust, eds.
Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Frontiers Media SA. doi. 10.3389/978-2-88963-429-3
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Xiu Hui Fun and Guillaume Thibault✉
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan doi. 10.1016/j.bbalip.2019.04.009
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2019
Sarita Hebbar, Elisabeth Knust, Guillaume Thibault✉, Rachel Kraut✉
Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Frontiers in Cell and Developmental Biology 2019 Dec 6. doi. 10.3389/fcell.2019.00327
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Wilson W.B. Goh✉, Subhash Thalappilly, Guillaume Thibault✉
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Drug Discovy Today 2019 Dec. doi. 10.1016/j.drudis.2019.08.008
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Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Cell Reports 2019 Jul 23. doi. 10.1016/j.celrep.2019.06.036
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Peter Shyu Jr*, Benjamin S.H. Ng*, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault✉
Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
Scientific Reports 2019 Jun 14. doi. 10.1038/s41598-019-45020-6
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Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault✉
Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans
Frontiers in Physiology 2019 May 28. doi. 10.3389/fphys.2019.00641
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2018
Jhee Hong Koh*, Lei Wang*, Caroline Beaudoin-Chabot, Guillaume Thibault✉
Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
Journal of Cell Science 2018 Nov 21. doi. 10.1242/jcs.217992
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Peter Shyu Jr*, Xing Fah Wong*, Karen Crasta✉, Guillaume Thibault✉
Dropping in on lipid droplets: insights into cellular stress and cancer
Bioscience Reports 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
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Nurulain Ho, Chengchao Xu, Guillaume Thibault✉
From the unfolded protein response to metabolic diseases - lipids under the spotlight
Journal of Cell Science 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
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2014
Haoxi Wu*, Benjamin S.H. Ng*, Guillaume Thibault✉
Endoplasmic Reticulum Stress Response in Yeast and Humans
Bioscience Reports 2014 Aug 1, 34(4). doi. 10.1042/BSR20140058
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2013
Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981. doi. 10.1126/science.1234055
Abstract I Full Text I Perspective in Science I Research Highlights in Nature Chemical Biology I Faculty Opinions
Guillaume Thibault✉ and Davis T. Ng
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525. doi. 10.1016/B978-0-12-378630-2.00427-8
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2012
Guillaume Thibault and Davis T. Ng
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harbor Perspectives in Biology 2012 Dec 3;4(12):a013193. doi. 10.1101/cshperspect.a013193
Abstract I Full Text
Guillaume Thibault , Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Molecular Cell 48, 16-27. doi. 10.1016/j.molcel.2012.08.016
Abstract I Full Text I PDF I Featured on the Cover I Faculty Opinions
Guillaume Thibault and Walid A. Houry
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
Journal of Physical Chemistry B 116, 6717-6724. doi. 10.1021/jp212024b
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2011
Guillaume Thibault*, Nurzian Ismail*, Davis T. Ng
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
PNAS 108, 20597-20602. doi. 10.1073/pnas.1117184109
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Songyu Wang, Guillaume Thibault, Davis T. Ng
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
Journal of Biological Chemistry 286, 29376-23987. doi. 10.1074/jbc.M111.233346
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Usheer Kanjee, Irina Gutsche, Eftichia Alexopoulos, Boyu Zhao, Majida El Bakkouri, Guillaume Thibault, Kaiyin Liu, Shaliny Ramachandran, Jamie Snider, Emil F. Pai. Walid A. Houry
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO Journal 30, 931-944. doi. 10.1038/emboj.2011.5
Abstract I Full Text I PDF I Faculty Opinions
2008
Jamie Snider*, Guillaume Thibault*, Walid A. Houry
The AAA+ superfamily of functionally diverse proteins
Genome Biology 9, 216. doi. 10.1186/gb-2008-9-4-216
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2006
Guillaume Thibault, Jovana Yudin, Philip Wong, Vladimir Tsitrin, Remco Sprangers, Rongmin Zhao, Walid A. Houry
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
PNAS 103, 17724-17729. doi. 10.1073/pnas.0601505103
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Guillaume Thibault*, Yulia Tsitrin*, Toni Davidson, Anna Gribun, Walid A. Houry
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO Journal 25, 3367-3376. doi. 10.1038/sj.emboj.7601223
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2003
Urszula A. Wojtyra*, Guillaume Thibault*, Ashleigh Tuite, Walid A. Houry
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
Journal of Biological Chemistry 278, 48981-48990. doi. 10.1074/jbc.M307825200
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