Malavika CHAKRAPANI
PhD Student
MSc. Cancer Cell and Molecular Biology | University of Leicester, United Kingdom
BSc. Life Sciences | Dayanand Sagar University, Bangalore, India
About
Malavika completed her Bachelor of Science in Life Sciences from Dayananda Sagar University, Bangalore, India, where she specialised in Biotechnology, Biochemistry and Genetics. She then pursued her Masters in Cancer Cell and Molecular Biology at the University of Leicester, United Kingdom, where her dissertation focused on targeting lactate metabolism in glioblastoma as a potential therapeutic strategy. Before joining the lab, she worked at bit.bio, Cambridge as a Research Assistant, where she was involved in generation and characterization of iPSC-derived human cell types. Her research interests centre on developing and applying human-relevant 3D model systems to study health and disease, with a broader interest in reducing reliance on conventional in vivo animal models through physiologically relevant human cell-based platforms.
Project
Malavika’s PhD project focuses on endoplasmic reticulum remodelling and quality control during intestinal lipid absorption. Using human iPSC-derived intestinal organoids, epithelial monolayers, ER reporter lines, and quantitative imaging approaches, she studies how intestinal epithelial cells adapt to physiological lipid exposure. Her work aims to define how ER architecture, ER-phagy, and lipid-handling pathways maintain epithelial homeostasis, and how their failure may contribute to chronic ER stress in ageing and disease.