Abhigna BATTINENI

PhD Student

MTech. Biotechnology | Indian Institute of Technology, Guwahati, India
BTech. Genetic Engineering | Bharath Institute of Higher Education and Research, Chennai, India

About

Abhigna completed her Bachelor’s in Biotechnology from Bharath Institute of Higher Education and Research, where she gained experience in microbial enzyme screening for biodegradation, as well as plant-based therapeutics through in vitro micropropagation. Driven by her interest in life sciences, she pursued a Master’s degree at the Indian Institute of Technology Guwahati. There, she worked on investigating disease-associated mutations in peroxisomal proteins using Saccharomyces cerevisiae as a model system, and developed a strong foundation in molecular biology and related techniques. Her research interests lie in understanding molecular mechanisms of disease and applying biological knowledge to address health and environmental challenges.

Project

Abhigna joined the Thibault Lab as a Ph.D. student in January 2024. Her research investigates the role of the Unfolded Protein Response (UPR), with a particular focus on the activity of the IRE1 protein, in aging under proteotoxic stress. Using deep mutational screening and structural analysis of IRE1, she aims to gain a deeper understanding of how IRE1 contributes to the maintenance of ER homeostasis during aging and how its activity during cellular stress responses impacts the aging process.

Publications

  1. I Kashyap, R Deb, A Battineni, S Nagotu, Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease, Molecular Genetics and Genomics 203;298 (6), 1247-1260, DOI: 10.1007/s00438-023-02059-5