Publications

Click here for all publications. ^co-first authors, *corresponding author.
X.H. Fun and G. Thibault* (2019)
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
 Biochim Biophys Acta, Mol Cell Biol Lipids
doi: 10.1016/j.bbalip.2019.04.009. IN PRESS 
Abstract  I  Full Text  I PDF
J.H. Koh^, L. Wang^, C. Beaudoin-Chabot, G. Thibault* (2018)
​Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
J Cell Sci 2018 Nov 21. doi: 10.1242/jcs.217992
Abstract  I  Full Text  I PDF
P.T. Jr Shyu^, X.F.A. Wong^, K. Crasta*, G. Thibault* (2018)
​Dropping in on lipid droplets: insights into cellular stress and cancer
Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Abstract  I  Full Text  I PDF
L. Wang, C. Beaudoin-Chabot, G. Thibault* (2018)
​Glucose increases the lifespan of post-reproductive C. elegans independently of FOXO
bioRxiv 2018 14 June. doi.org/10.1101/347435
Abstract  I  PDF
B.S.H Ng, P.T. Jr Shyu, N. Ho, R. Chaw, Y.L. Seah, G. Thibault* (2018)
A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation
bioRxiv 2018 11 June. doi.org/10.1101/178947
Abstract  I  PDF
N. Ho, C. Xu, G. Thibault* (2018)
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). doi: 10.1242/jcs.199307
Abstract  I  Full Text  I  PDF
H. Wu^, B.S.H. Ng^, G. Thibault* (2014)
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep 2014 Aug 1, 34(4). doi:10.1042/BSR20140058
Abstract  I  Full Text  I  PDF
C. Xu, S. Wang, G. Thibault, D.T. Ng (2013)
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981
Abstract  I  Full Text I Perspective in Science  I  Research Highlights in Nature Chemical Biology  I  Faculty of 1000 Evaluation
G. Thibault* and D.T. Ng (2013)
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525
Full Text
G. Thibault and D.T. Ng (2012)
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193
Abstract  I  Full Text
G. Thibault , G. Shui, W. Kim, G.C. McAlister, N. Ismail, S.P. Gygi, M.R. Wenk, D.T. Ng (2012)
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27
Abstract  I  Full Text  I PDF I Featured on the Cover  I  Faculty of 1000 Evaluation
G. Thibault and W.A. Houry (2012)
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724
Abstract  I  Full Text
G. Thibault^ N. Ismail^, D.T. Ng (2011)
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602.
Abstract  I  Full Text  I PDF
S. Wang, G. Thibault, D.T. Ng (2011)
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987
Abstract  I  Full Text  I PDF
G. Thibault* and D.T. Ng (2011)
A screen for mutants requiring activation of the unfolded protein response for viability
Methods in Enzymol 491, 199-216.
Abstract  I  Full Text
U. Kanjee, I. Gutsche, E. Alexopoulos, B. Zhao, M. El Bakkouri, G. Thibault, K. Liu, S. Ramachandran, J. Snider, E.F. Pai. W.A. Houry (2011)
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944
Abstract  I  Full Text  I PDF I Faculty of 1000 Evaluation
J. Snider^, G. Thibault^, W.A. Houry (2008)
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216.
Abstract  I  Full Text  I PDF
G. Thibault, J. Yudin, P. Wong, V. Tsitrin, R. Sprangers, R. Zhao, W. A Houry (2006)
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729
Abstract  I  Full Text  I PDF
G. Thibault^, Y. Tsitrin^, T. Davidson, A. Gribun, W.A. Houry (2006)
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376.
Abstract  I  Full Text  I PDF
U. A. Wojtyra^, G. Thibault^, A. Tuite, W. A. Houry (2003)
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990.
Abstract  I  Full Text  I PDF

Preprint replaced by peer reviewed publication

J.H. Koh^, L. Wang^, C. Beaudoin-Chabot, G. Thibault* (2018)
​Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress
bioRxiv 2018 20 March. doi.org/10.1101/285379
Abstract  I  PDF