Publications

Click here for all publications. ^co-first authors, *corresponding author.
P.T. Jr Shyu^, X.F.A. Wong^, K. Crasta*, G. Thibault* (2018)
​Dropping in on lipid droplets: insights into cellular stress and cancer
Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Abstract  I  Full Text  I PDF
L. Wang, C. Beaudoin-Chabot, G. Thibault* (2018)
​Glucose increases the lifespan of post-reproductive C. elegans independently of FOXO
bioRxiv 2018 14 June. doi.org/10.1101/347435
Abstract  I  PDF
B.S.H Ng, P.T. Jr Shyu, N. Ho, R. Chaw, Y.L. Seah, G. Thibault* (2018)
A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation
bioRxiv 2018 11 June. doi.org/10.1101/178947
Abstract  I  PDF
J.H. Koh^, L. Wang^, C. Beaudoin-Chabot, G. Thibault* (2018)
​Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress
bioRxiv 2018 20 March. doi.org/10.1101/285379 *co-first authors
Abstract  I  PDF
N. Ho, C. Xu, G. Thibault* (2018)
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). pii: jcs199307
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H. Wu^, B.S.H. Ng^, G. Thibault* (2014)
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep 2014 Aug 1, 34(4). doi:10.1042/BSR20140058
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C. Xu, S. Wang, G. Thibault, D.T. Ng (2013)
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981
Abstract  I  Full Text I Perspective in Science  I  Research Highlights in Nature Chemical Biology  I  Faculty of 1000 Evaluation
G. Thibault* and D.T. Ng (2013)
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525
Full Text
G. Thibault and D.T. Ng (2012)
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193
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G. Thibault , G. Shui, W. Kim, G.C. McAlister, N. Ismail, S.P. Gygi, M.R. Wenk, D.T. Ng (2012)
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27
Abstract  I  Full Text  I PDF I Featured on the Cover  I  Faculty of 1000 Evaluation
G. Thibault and W.A. Houry (2012)
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724
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G. Thibault^ N. Ismail^, D.T. Ng (2011)
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602.
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S. Wang, G. Thibault, D.T. Ng (2011)
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987
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G. Thibault* and D.T. Ng (2011)
A screen for mutants requiring activation of the unfolded protein response for viability
Methods in Enzymol 491, 199-216.
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U. Kanjee, I. Gutsche, E. Alexopoulos, B. Zhao, M. El Bakkouri, G. Thibault, K. Liu, S. Ramachandran, J. Snider, E.F. Pai. W.A. Houry (2011)
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944
Abstract  I  Full Text  I PDF I Faculty of 1000 Evaluation
J. Snider^, G. Thibault^, W.A. Houry (2008)
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216.
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G. Thibault, J. Yudin, P. Wong, V. Tsitrin, R. Sprangers, R. Zhao, W. A Houry (2006)
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729
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G. Thibault^, Y. Tsitrin^, T. Davidson, A. Gribun, W.A. Houry (2006)
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376.
Abstract  I  Full Text  I PDF
U. A. Wojtyra^, G. Thibault^, A. Tuite, W. A. Houry (2003)
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990.
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