Publications

CLICK HERE for all publications. *co-first authors; bold, Thibault lab members; ✉corresponding author.

2022

R. Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabot, Cenk Celik, I. Lebenthal-Loinger, S. Karato-Lampert, Syed Ahmad-Albukhari, Guillaume Thibault, S. Henis-Korenblit✉​
Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
Cell Reports IN PRESS
Cenk Celik*, Stella Yue Ting Lee*, Wei Sheng Yap, Guillaume Thibault✉
Endoplasmic reticulum stress and lipids in health and diseases
Prog Lipid Res 2022 Nov 13. doi.10.1016/j.plipres.2022.101198
Abstract | Full Text | PDF
Wei Sheng Yap and Guillaume Thibault✉
A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE
MicroPubl Biol 2022 Oct 26. doi.10.17912/micropub.biology.000657
​Abstract | Full Text | PDF | Data Repository
Caroline Beaudoin-Chabot*, Lei Wang*, Cenk Celik, Aishah T.F. Abdul Khalid, Subbash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus W.X. Lim, Ann Don Low, and Guillaume Thibault✉
The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans
​Nat Commun 2022 Oct 19. doi. 10.1038/s41467-022-33630-0
Abstract | Full Text | PDF | Data Repository
NTU NEWS | NTU Press Release
Local Media Coverage CNA938 Singapore Today, Straits Times, zaobao
International Media Coverage Big News Network, Borneo Bulletin, Canaltech, Forbes Russia, Psychreg, Revyuh, terra, and Yahoo! News
Wei Sheng Yap and Guillaume Thibault✉
Human PERK rescues unfolded protein response-deficient yeast cells
MicroPubl Biol 2022 Jun 22. doi. 10.17912/micropub.biology.000592
​Abstract | Full Text | PDF | Data Repository
Sophia Huey Shan Tan✉, Guillaume Thibault✉, Anna Chia Yin Chew, Preman Rajalingam
Enabling open-ended questions in team-based learning using automated marking: Impact on student achievement, learning and engagement
J Comput Assist Learn 2022 May 2. doi. ​10.1111/jcal.12680
​Full Text I PDF

2021

Nurulain Ho*, Wei Sheng Yap*, Guillaume Thibault✉
A high-throughput genetic screening protocol to measure lipid bilayer stress-induced unfolded protein response in Saccharomyces cerevisiae
STAR Protoc 2021 Dec 17. doi. ​10.1016/j.xpro.2021.100868
​Abstract I Full Text I PDF
K. Rizzolo, A.Y.H. Yu, A. Ologbenla, S.R. Kim, H. Zhu, K. Ishimori, Guillaume Thibault, E. Leung, Y.W. Zhang, M. Teng, M. Haniszewski, N. Miah, S. Phanse, Z. Minic, S. Lee, J.D. Caballero, M. Babu, F.T.F. Tsai, T. Saio, W.A. Houry
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
Nat Commun 2021 Jan 12. doi. 10.1038/s41467-020-20553-x
Abstract  I  Full Text  I  PDF
Guillaume Thibault, Davis T. Ng, Vikash Verma
Concepts | Heat/Stress Responses
Encyclopedia of Biological Chemistry III, Academic Press, Waltham, 2021, 97-101. doi. 10.1016/B978-0-12-819460-7.00189-4
​Full Text

2020

Wei Sheng Yap*, Peter Shyu Jr.*, Maria Laura Gaspar, Stephen A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉
The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis
J Cell Sci 2020 Nov 5. doi. ​10.1242/jcs.248526
Abstract  I  Full Text​  I PDF  I Data Repository
Article was featured in Research Highlight
Wei Sheng Yap was featured as First Person in the same issue
Preprint of this pubilcation was highlighted in preLights
Nurulain Ho*, Wei Sheng Yap*, Jiaming Xu*, Haoxi Wu*,  Jhee Hong Koh, Wilson W.B. Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉
​Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
J Cell Biol 2020 Apr 29. doi. 10.1083/jcb.201909165
Abstract  I  Full Text  I PDF  I Data Repository
Rachel S. Kraut, Guillaume Thibault, Sarita Hebbar, Elisabeth Knust, eds.
Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Frontiers Media SA. doi. 10.3389/978-2-88963-429-3
Ebook PDF I Ebook EPUB
Xiu Hui Fun and Guillaume Thibault✉
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Biochim Biophys Acta, Mol Cell Biol Lipids 2020 Jan  doi. 10.1016/j.bbalip.2019.04.009
Abstract  I  Full Text  I PDF

2019

Sarita Hebbar, Elisabeth Knust, Guillaume Thibault✉, Rachel Kraut✉
Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
Front Cell Dev Biol 2019 Dec 6. doi. 10.3389/fcell.2019.00327
Full Text I  PDF
Wilson W.B. Goh✉, Subhash Thalappilly, Guillaume Thibault✉
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Drug Discov Today 2019 Dec. doi. 10.1016/j.drudis.2019.08.008
Abstract  I  Full Text  I PDF
Kizito Njah, Sayan Chakraborty, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Cell Rep 2019 Jul 23. doi. 10.1016/j.celrep.2019.06.036
Abstract  I  Full Text  I PDF
Peter Shyu Jr*, Benjamin S.H. Ng*, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Charlie Marvalim, Guillaume Thibault✉
Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
Sci Rep 2019 Jun 14. doi. 10.1038/s41598-019-45020-6
Abstract  I  Full Text  I PDF
Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidovic, Mikhail S. Shchepinov, Guillaume Thibault✉
Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans​
Front Physiol 2019 May 28. doi. 10.3389/fphys.2019.00641
​Abstract  I  Full Text  I PDF  I  Data Repository

2018

Jhee Hong Koh*, Lei Wang*, Caroline Beaudoin-Chabot, Guillaume Thibault✉
​Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
J Cell Sci 2018 Nov 21. doi. 10.1242/jcs.217992
Abstract  I  Full Text  I PDF  I Data Repository
Peter Shyu Jr*, Xing Fah Wong*, Karen Crasta✉, Guillaume Thibault✉
​Dropping in on lipid droplets: insights into cellular stress and cancer
Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Abstract  I  Full Text  I PDF
Nurulain Ho, Chengchao Xu, Guillaume Thibault✉
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
Abstract  I  Full Text  I  PDF

2014

Haoxi Wu*, Benjamin S.H. Ng*, Guillaume Thibault✉
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep 2014 Aug 1, 34(4). doi. 10.1042/BSR20140058
Abstract  I  Full Text  I  PDF

2013

Chengchao Xu, Songyu Wang, Guillaume Thibault, Davis T. Ng
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981. doi. 10.1126/science.1234055
Abstract  I  Full Text I Perspective in Science  I  Research Highlights in Nature Chemical Biology  I  Faculty Opinions
Guillaume Thibault✉ and Davis T. Ng
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525. doi. 10.1016/B978-0-12-378630-2.00427-8
Full Text

2012

Guillaume Thibault and Davis T. Ng
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193. doi. 10.1101/cshperspect.a013193
Abstract  I  Full Text
Guillaume Thibault , Guanghou Shui, Woong Kim, Graeme C. McAlister, Nurzian Ismail, Steven P. Gygi, Markus R. Wenk, Davis T. Ng
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27. doi.  10.1016/j.molcel.2012.08.016
Abstract  I  Full Text  I PDF I Featured on the Cover  I  Faculty Opinions
Guillaume Thibault and Walid A. Houry
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724. doi. 10.1021/jp212024b
Abstract  I  Full Text

2011

Guillaume Thibault*, Nurzian Ismail*, Davis T. Ng
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602. doi. 10.1073/pnas.1117184109
Abstract  I  Full Text  I PDF
Songyu Wang, Guillaume Thibault, Davis T. Ng
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987. doi. 10.1074/jbc.M111.233346
Abstract  I  Full Text  I PDF
Guillaume Thibault* and Davis T. Ng
A screen for mutants requiring activation of the unfolded protein response for viability
Methods in Enzymol 491, 199-216. doi. 10.1016/B978-0-12-385928-0.00012-2
Abstract I  Full Text
Usheer Kanjee, Irina Gutsche, Eftichia Alexopoulos, Boyu Zhao, Majida El Bakkouri, Guillaume Thibault, Kaiyin Liu, Shaliny Ramachandran, Jamie Snider, Emil F. Pai. Walid A. Houry
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944. doi. 10.1038/emboj.2011.5
Abstract  I  Full Text  I PDF I Faculty Opinions

2008

Jamie Snider*, Guillaume Thibault*, Walid A. Houry
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216. doi. 10.1186/gb-2008-9-4-216
Abstract  I  Full Text  I PDF

2006

Guillaume Thibault, Jovana Yudin, Philip Wong, Vladimir Tsitrin, Remco Sprangers, Rongmin Zhao, Walid A. Houry
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729. doi. 10.1073/pnas.0601505103
Abstract  I  Full Text  I PDF
Guillaume Thibault*, Yulia Tsitrin*, Toni Davidson, Anna Gribun, Walid A. Houry
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376. doi. 10.1038/sj.emboj.7601223
Abstract  I  Full Text  I PDF

2003

Urszula A. Wojtyra*, Guillaume Thibault*, Ashleigh Tuite, Walid A. Houry
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990. doi. 10.1074/jbc.M307825200
Abstract  I  Full Text  I PDF

Preprint replaced by peer-reviewed publications

Peter Shyu Jr, Wei Sheng Yap, Maria Laura Gaspar, Stephan A. Jesch, Charlie Marvalim, William A. Prinz, Susan A. Henry, Guillaume Thibault✉
​Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis
bioRxiv 2020 April 15. doi. 10.1101/2020.04.06.027847
Abstract  I  PDF
This preprint is highlighted in preLights doi. 10.1242/prelights.19358
Nurulain Ho*, Haoxi Wu*, Jiaming Xu*, Jhee Hong Koh, Wei Sheng Yap, Wilson W.B. Goh, Shu Chen Chong, Stefan Taubert, Guillaume Thibault✉
​ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
bioRxiv 2019 Sep 18. doi. 10.1101/774133
Abstract  I  PDF
Lei Wang, Caroline Beaudoin-Chabot, Guillaume Thibault✉
​Glucose increases the lifespan of post-reproductive C. elegans independently of FOXO
bioRxiv 2018 14 June. doi. 10.1101/347435
Abstract  I  PDF
Benjamin S.H Ng, Peter Shyu Jr, Nurulain Ho, Ruijie Chaw, Yi Ling Seah, Guillaume Thibault✉ (2018)
A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation
bioRxiv 2018 11 June. doi.org/10.1101/178947
Abstract  I  PDF
Jhee Hong Koh*, Lei Wang*, Caroline Beaudoin-Chabot, Guillaume Thibault✉ (2018)
​Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress
bioRxiv 2018 20 March. doi.org/10.1101/285379
Abstract  I  PDF