Publications

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preprints

Learn more about preprints in the life sciences ASAPbio.org​
J.H. Koh*, E. Wang*, C. Beaudoin-Chabot, G. Thibault (2018)
​Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress
bioRxiv. 2018 20 March. doi: https://doi.org/10.1101/285379 *co-first authors
Abstract  I  PDF
B.S.H Ng, P.T. Jr Shyu, R. Chaw, Y.L. Seah, G. Thibault (2017)
​Lipid perturbation compromises UPR-mediated ER homeostasis as a result of premature degradation of membrane proteins
bioRxiv. 2017 21 August. doi: https://doi.org/10.1101/178947
Abstract  I  PDF

​Peer-reviewed publications

N. Ho, C. Xu, G. Thibault (2018)
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). pii: jcs199307
Abstract  I  Full Text  I  PDF
H. Wu*, B.S.H. Ng*, G. Thibault (2014)
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep.34(4):art:e00118.doi:10.1042/BSR20140058 *co-first authors
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C. Xu, S. Wang, G. Thibault, D.T. Ng (2013)
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981
Abstract  I  Full Text I Perspective in Science  I  Research Highlights in Nature Chemical Biology  I  Faculty of 1000 Evaluation
G. Thibault and D.T. Ng (2013)
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525
Full Text
G. Thibault and D.T. Ng (2012)
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193
Abstract  I  Full Text
G. Thibault , G. Shui, W. Kim, G.C. McAlister, N. Ismail, S.P. Gygi, M.R. Wenk, D.T. Ng (2012)
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27
Abstract  I  Full Text  I PDF I Featured on the Cover  I  Faculty of 1000 Evaluation
G. Thibault and W.A. Houry (2012)
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724
Abstract  I  Full Text
G. Thibault* N. Ismail*, D.T. Ng (2011)
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602. *co-first authors
Abstract  I  Full Text  I PDF
S. Wang, G. Thibault, D.T. Ng (2011)
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987
Abstract  I  Full Text  I PDF
G. Thibault* and D.T. Ng (2011)
A screen for mutants requiring activation of the unfolded protein response for viability
Methods in Enzymol 491, 199-216. *Corresponding author
Abstract  I  Full Text
U. Kanjee, I. Gutsche, E. Alexopoulos, B. Zhao, M. El Bakkouri, G. Thibault, K. Liu, S. Ramachandran, J. Snider, E.F. Pai. W.A. Houry (2011)
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944
Abstract  I  Full Text  I PDF I Faculty of 1000 Evaluation
J. Snider*, G. Thibault*, W.A. Houry (2008)
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216. *co-first authors
Abstract  I  Full Text  I PDF
G. Thibault, J. Yudin, P. Wong, V. Tsitrin, R. Sprangers, R. Zhao, W. A Houry (2006)
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729
Abstract  I  Full Text  I PDF
G. Thibault*, Y. Tsitrin*, T. Davidson, A. Gribun, W.A. Houry (2006)
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376. *co-first authors
Abstract  I  Full Text  I PDF
U. A. Wojtyra*, G. Thibault*, A. Tuite, W. A. Houry (2003)
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990. *co-first authors
Abstract  I  Full Text  I PDF