Publications

CLICK HERE for all publications. ^co-first authors, *corresponding author.

2019

N. Ho^, H. Wu^, J. Xu^, J.H. Koh, W.S. Yap, W.W.B. Goh, S.C. Chong, S. Taubert, G. Thibault*
​ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
bioRxiv 2019 September 18. doi. 10.1101/774133
Abstract  I  PDF
W.W.B. Goh*, S. Thalappilly, G.Thibault*
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Drug Discov Today 2019 IN PRESS. doi. 10.1016/j.drudis.2019.08.008
Abstract  I  Full Text  I PDF
K. Njah, S. Chakraborty, B. Qiu, S. Arumugam, A. Raju, A.V. Pobbati, M. Lakshmanan, V. Tergaonkar, G. Thibault, X. Wang, W. Hong
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Cell Rep 2019 July 23. doi. 10.1016/j.celrep.2019.06.036
Abstract  I  Full Text  I PDF
P.T. Jr Shyu^, B.S.H Ng^, N. Ho, R. Chaw, Y.L. Seah, C. Marvalim, G. Thibault*
Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
Sci Rep 2019 June 14. doi. 10.1038/s41598-019-45020-6
Abstract  I  Full Text  I PDF
C. Beaudoin-Chabot, L. Wang, A.V. Smarun, D. Vidovic, M.S. Shchepinov, G. Thibault*
Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans​
Front Physiol 2019 May 28. doi. 10.3389/fphys.2019.00641
​Abstract  I  Full Text  I PDF
X.H. Fun and G. Thibault*
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Biochim Biophys Acta, Mol Cell Biol Lipids 2019 IN PRESS.  doi. 10.1016/j.bbalip.2019.04.009
Abstract  I  Full Text  I PDF

2018

J.H. Koh^, L. Wang^, C. Beaudoin-Chabot, G. Thibault*
​Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
J Cell Sci 2018 Nov 21. doi. 10.1242/jcs.217992
Abstract  I  Full Text  I PDF
P.T. Jr Shyu^, X.F.A. Wong^, K. Crasta*, G. Thibault*
​Dropping in on lipid droplets: insights into cellular stress and cancer
Biosci Rep 2018 Sep 19, 38(5). doi.10.1042/BSR20180764
Abstract  I  Full Text  I PDF
L. Wang, C. Beaudoin-Chabot, G. Thibault*
​Glucose increases the lifespan of post-reproductive C. elegans independently of FOXO
bioRxiv 2018 14 June. doi. 10.1101/347435
Abstract  I  PDF
N. Ho, C. Xu, G. Thibault*
From the unfolded protein response to metabolic diseases - lipids under the spotlight
J Cell Sci 2018 Feb 8;131(3). doi. 10.1242/jcs.199307
Abstract  I  Full Text  I  PDF

2014

H. Wu^, B.S.H. Ng^, G. Thibault*
Endoplasmic Reticulum Stress Response in Yeast and Humans
Biosci Rep 2014 Aug 1, 34(4). doi. 10.1042/BSR20140058
Abstract  I  Full Text  I  PDF

2013

C. Xu, S. Wang, G. Thibault, D.T. Ng
Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway
Science 340, 978-981. doi. 10.1126/science.1234055
Abstract  I  Full Text I Perspective in Science  I  Research Highlights in Nature Chemical Biology  I  Faculty of 1000 Evaluation
G. Thibault* and D.T. Ng
Heat/Stress Responses
Encyclopedia of Biological Chemistry, Academic Press, Waltham, 2013, 522-525. doi. 10.1016/B978-0-12-378630-2.00427-8
Full Text

2012

G. Thibault and D.T. Ng
The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast
Cold Spring Harb Perspect Biol 2012 Dec 3;4(12):a013193. doi. 10.1101/cshperspect.a013193
Abstract  I  Full Text
G. Thibault , G. Shui, W. Kim, G.C. McAlister, N. Ismail, S.P. Gygi, M.R. Wenk, D.T. Ng
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network
Mol Cell 48, 16-27. doi.  10.1016/j.molcel.2012.08.016
Abstract  I  Full Text  I PDF I Featured on the Cover  I  Faculty of 1000 Evaluation
G. Thibault and W.A. Houry
The role of the N-terminal domain of the chaperone ClpX in recognition and degradation of lambda phage protein O
J Phys Chem B 116, 6717-6724. doi. 10.1021/jp212024b
Abstract  I  Full Text

2011

G. Thibault^ N. Ismail^, D.T. Ng
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway
Proc Natl Acad Sci U S A 108, 20597-20602. doi. 10.1073/pnas.1117184109
Abstract  I  Full Text  I PDF
S. Wang, G. Thibault, D.T. Ng
Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity
J Biol Chem 286, 29376-23987. doi. 10.1074/jbc.M111.233346
Abstract  I  Full Text  I PDF
G. Thibault* and D.T. Ng
A screen for mutants requiring activation of the unfolded protein response for viability
Methods in Enzymol 491, 199-216. doi. 10.1016/B978-0-12-385928-0.00012-2
Abstract I  Full Text
U. Kanjee, I. Gutsche, E. Alexopoulos, B. Zhao, M. El Bakkouri, G. Thibault, K. Liu, S. Ramachandran, J. Snider, E.F. Pai. W.A. Houry
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
EMBO J 30, 931-944. doi. 10.1038/emboj.2011.5
Abstract  I  Full Text  I PDF I Faculty of 1000 Evaluation

2008

J. Snider^, G. Thibault^, W.A. Houry
The AAA+ superfamily of functionally diverse proteins
Genome Biol 9, 216. doi. 10.1186/gb-2008-9-4-216
Abstract  I  Full Text  I PDF

2006

G. Thibault, J. Yudin, P. Wong, V. Tsitrin, R. Sprangers, R. Zhao, W. A Houry
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Proc Natl Acad Sci U S A 103, 17724-17729. doi. 10.1073/pnas.0601505103
Abstract  I  Full Text  I PDF
G. Thibault^, Y. Tsitrin^, T. Davidson, A. Gribun, W.A. Houry
Large-scale nucleotide-dependent movement of the N-terminal zinc binding domain of ClpX: implications for chaperone function and regulation
EMBO J 25, 3367-3376. doi. 10.1038/sj.emboj.7601223
Abstract  I  Full Text  I PDF

2003

U. A. Wojtyra^, G. Thibault^, A. Tuite, W. A. Houry
The N-terminal zinc binding domain of ClpX is a substrate sensing and dimerization domain that modulates the chaperone function
J Biol Chem 278, 48981-48990. doi. 10.1074/jbc.M307825200
Abstract  I  Full Text  I PDF

Preprint replaced by peer reviewed publications

B.S.H Ng, P.T. Jr Shyu, N. Ho, R. Chaw, Y.L. Seah, G. Thibault* (2018)
A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation
bioRxiv 2018 11 June. doi.org/10.1101/178947
Abstract  I  PDF
J.H. Koh^, L. Wang^, C. Beaudoin-Chabot, G. Thibault* (2018)
​Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress
bioRxiv 2018 20 March. doi.org/10.1101/285379
Abstract  I  PDF